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DNA Vaccine Protects Mice Against Porphyromonas gingivalis.(Brief Article)
2001 MAY 9 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A DNA vaccine based on arginine-specific cysteine proteinase RgpA promoted antibodies against Porphyromonas gingivalis and protected mice from gingivitis.
P. gingivalis produces RgpA and RgpB, which are thought to interrupt host defense mechanisms and to destroy periodontal connective tissue.
"To induce a protective immune response against P. gingivalis, we constructed an rgpA DNA vaccine," reported Y. Yonezawa and colleagues at Tokyo Dental College in Chiba, Japan. "BALB/c mice were immunized intradermally by gene gun with plasmid DNA carrying rgpA."
Vaccinated mice exhibited high levels of serum antibodies against P. gingivalis, as measured by enzyme-linked immunosorbent assay (ELISA). The vaccine apparently was able to mitigate the activity of both RgpA and RgpB and inhibit the ability of P. gingivalis to bind to a type I collagen sponge, reported Yonezawa and team.
They observed that mouse sera were able to reduce the hemagglutination of P. gingivalis after vaccination, which pointed to an association between hemagglutinin activity and RgpA.
Vaccinated mice also were resistant to a challenge with invasive P. gingivalis W50, the researchers ...
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