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Adjuvants Improve Potency Of Epidermal Powder Immunization.(Brief Article)
2001 MAY 9 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Epidermal powder immunization (EPI) is an attractive delivery route for vaccination and has shown some success in mice immunized against influenza.
Now researchers working in American confirm that using adjuvants with EPI further enhances the immune response to the antigen delivered.
D. Chen and colleagues noted a 25- to 250-fold improvement in immunoglobulin G (IgG) antibody response following the addition of alum or a synthetic oligonucleotide containing CpG DNA motifs (CpG DNA) to diphtheria toxoid delivered by EPI.
They noted that this antibody response was long-lasting and that the addition of alum promoted a response similar to that seen with diphtheria injection vaccine, indicative of Th-2 immunity, while addition of CpG DNA led to a Th-1 type of response ("Adjuvantation of epidermal powder immunization, Vaccine, April 6, 2001;19(20-22):2908-2917).
"This study indicated that EPI using appropriate adjuvants can produce an augmented antibody response and desirable ...
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