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Immunized Hamsters Partially Protected From Parasite-Induced Sequelae.(Brief Article)
2001 MAY 9 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Vaccinating hamsters with hookworm antigen partially protects them from anemia and weight loss, without actually reducing parasite burden.
"Hookworms are a leading cause of anemia in developing countries, and a strategy aimed at reducing pathology caused by blood-feeding adult parasites would be a valuable addition to global control efforts," said R.D. Bungiro Jr. and colleagues at Yale University.
They observed that Syrian golden hamsters previously infected with Ancylostoma ceylanicum hookworm had acquired long-term resistance to the major sequelae of infection: weight loss and anemia. Transfer of pooled serum from hamsters with secondary infection to those with primary infection conferred partial resistance to growth delay and anemia, reported Bungiro et al ("Mitigation of hookworm disease by immunization with soluble extracts of Ancylostoma ceylanicum," Journal of Infectious Diseases, May 1, 2001;183(9):1380-1387).
When the researchers vaccinated hamsters with soluble adult hookworm ...
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Source: HighBeam Research, Immunized Hamsters Partially Protected From Parasite-Induced...