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Immunization With GA733 Antigen Induces Immunity In Cancer Patients.(Brief Article)
2001 MAY 9 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Patients with pancreatic and colorectal cancer show enhanced immune response after immunization with the GA733 antigen, Wistar Institute researchers report.
"Targeting the GA733 antigen (also known as CO17-1A, EGP, KS1-4, KSA, Ep CAM) by monoclonal antibody C017-1A or anti-idiotypic antibodies mimicking the CO17-1A or GA733 epitope has induced prolonged survival and specific immune responses to the antigen, respectively, in colorectal cancer (CRC) patients," said L. Staib and colleagues.
They proposed that because GA733-2E was superior to anti-idiotypic antibodies at modulating specific immune responses in preclinical studies, alum-precipitated GA733-2E might be effective in patients with resected CRC or pancreatic cancer.
Staib and colleagues immunized six patients with advanced pancreatic cancer and six with Dukes' stage A, B, or C colorectal cancer with four to seven doses of GA733-2E at 50, 200 or 800 (micro)g per dose every month.
Six of the 12 patients showed antigen-specific humoral responses and eight showed cellular responses, for an overall immune response rate of 83%, reported Staib and team.
Pancreatic cancer patients had a median survival time of 11.2 months, while CRC patients had a median survival of 39.8 months ("Immunogenicity of recombinant GA733-2E antigen (CO17-1A, EGP, KS1-4, KSA, Ep-CAM) in gastro-intestinal carcinoma patients," International ...
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