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Demonstration of Cross-Reactive Epitopes Should Enhance Vaccine Development.(Brief Article)
2001 MAY 9 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - By identifying cross-reactive epitopes on the surface of erythrocytes parasitized by Plasmodium falciparum, researchers at the U.S. National Institutes of Health have overcome a major hurdle to effective vaccine development.
"Plasmodium falciparum parasites evade the host immune system by clonal expression of the variant antigen P. falciparum erythrocyte membrane protein 1 (PfEMP1)," explained B. Gamain and colleagues.
Because PfEMP1 is variant-specific, vaccine development in this area has been limited. To overcome this challenge, Gamain and team set out to identify cross-reactive epitopes on parasitized erythrocytes (PEs). "We prepared monoclonal antibodies (MAbs) to the cysteine-rich interdomain region 1 (CIDR1) of PfEMP1 that is functionally conserved for binding to CD36," they reported.
The researchers found two MAbs that reacted with multiple P. falciparum strains expressing variant PfEMP1s, one of which recognized nine of 10 strains. Both MAbs recognized the CIDR1 of various PfEMP1s in Chinese hamster ovary cells, demonstrating that they were "truly cross-reactive," the authors said ("The surface variant antigens of Plasmodium falciparum contain cross-reactive epitopes," Proceedings of the National Academy of Sciences of the ...
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Source: HighBeam Research, Demonstration of Cross-Reactive Epitopes Should Enhance Vaccine...