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Obese 'Apple-Shaped' Women At Risk For Type II Diabetes And Heart Disease.
2001 APR 26 - (NewsRx Network) -- Although it is not known why some women are apple-shaped and others are pear-shaped, researchers at the University of Southampton, U.K., believe that abnormalities in the way insulin works may provide the answer.
Insulin is a key hormone that controls the metabolism of carbohydrate, fat, and protein in many tissues including skeletal muscle, fat, and the liver.
Dr. Richard Holt, of the University Department of Fetal Origins of Disease, said: "There are very strong links between obesity and type 2 diabetes and heart disease. It is not just being obese that matters but where the fat is laid down. If you are apple-shaped you are much more likely to get these problems than if you are pear-shaped and the risks are higher for women than for men. We want to find out why that is.
"We believe a key factor is insulin resistance. We are looking at how insulin works in liver, fat and muscle in different shaped women and how important this is for development of disease," Holt continued.
The Southampton team led by Holt and Prof. Chris Byrne aim to recruit 40 healthy, middle-aged, overweight women, half of whom are apple-shaped and the other half pear-shaped.
Detailed body measurements will be done and participants will complete physical activity and quality of life questionnaires. Blood tests will also enable doctors to look at insulin action and its relationship to fat and glucose metabolism.
A second part of the research will be done in ...
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Source: HighBeam Research, Obese 'Apple-Shaped' Women At Risk For Type II Diabetes And Heart...