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Tamoxifen Use Not Associated With Decreased Sexual Functioning Or Mood Swings.
2001 APR 19 - (NewsRx.com & NewsRx.net) -- Long-term use of tamoxifen does not affect mood or sexual functioning as has been speculated, according to researchers in Britain who studied use of the anti-estrogen drug in women at high risk of developing breast cancer.
Culling information from two ongoing, British, double-blind, randomized trials of tamoxifen versus use of a placebo over five years in 488 women, the researchers found that, as expected, tamoxifen users had significantly more hot flashes (42% vs. 29%), night sweats (43% vs. 29%), and cold sweats (10% vs.
3%), compared to the control group. Tamoxifen blocks the brain's use of estrogen, thus producing menopause-like symptoms.
But, beyond these menopausal symptoms, there were no significant quality-of-life differences between the groups, and no effect of tamoxifen on overall sexual activity (80% of tamoxifen users were sexually active compared to 75% in the placebo group), the researchers said (Fallowfield et al., 'Tamoxifen for the prevention of breast cancer: Psychosocial impact on women participating in two randomized controlled trials," Journal of ...
- New Research Indicates Safety of RemiFemin for Menopausal Symptoms in Breast...
- Press release article from: PR Newswire October 3, 2002 700+ words
...cohosh extract, estrogen, tamoxifen (an anti-estrogen) and...estrogen) controls, as well as tamoxifen. When black cohosh was introduced...the inhibitory effect of tamoxifen, a commonly prescribed drug...this data supports the non-estrogenic effects of Remifemin in the breast...
- Soy isoflavone aglycones have estrogenic effects on mouse reproductive tracts.
- Newspaper article from: Health & Medicine Week March 1, 2004 700+ words
...net) -- Isoflavone aglycones have estrogenic effects on mouse reproductive tracts. According...10D concentrates caused dramatic estrogenic effects in both male and female mice...ratio of 2:1 or less has marked estrogenic effects on the reproductive system of male...
- Estrogenic effects of two derivatives of icariin on human breast cancer MCF-7...
- Magazine article from: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology Ye, H.Y. Lou, Y.J. November 1, 2005 700+ words
Abstract The aims of the present study were to determine the estrogenic activities of icariin (ICA) and its derivatives and their structure-estrogenic activity relationship. Therefore, icaritin (ICT) and desmethylicaritin (DICT) were derived from ICA. The estrogenic activities of ICA, ICT and DICT
- Monitoring estrogenic effects: a genomics approach. (Science Selections).
- Magazine article from: Environmental Health Perspectives Eubanks, Mary May 15, 2003 700+ words
Genomics, the revolutionary field that promises to one day reveal the genetic code of every living organism, is opening up unforeseen opportunities for advances in many areas of the life sciences. In this issue, a team led by Patrick Larkin of the University of Florida in Gainesville and EcoArray
- 'Estrogen' pairings can increase potency. (synergistic estrogenic effects...
- Magazine article from: Science News Raloff, Janet June 8, 1996 700+ words
Toxicologist John A. McLachlan and his coworkers made a startling observation 2 years ago: A pair of polychlorinated biphenyls (PCBs) delivered together had up to 20 times the ability to switch the sex of incubating turtles as either of these weak estrogen mimics had when delivered alone (SN:
- Does Long-Term Use of Tamoxifen Up Ca Risk?
- Magazine article from: OB GYN News JANCIN, BRUCE March 15, 2001 700+ words
...regarding the merits of using tamoxifen to reduce breast cancer...preclinical data in arguing that tamoxifen's mixed estrogenic and anti-estrogenic effects could spell trouble in...even with 10 years of tamoxifen use, compared with 2...
- Tamoxifen alone discouraged as adjuvant Tx.(Gynecology)
- Magazine article from: OB GYN News Mahoney, Diana May 1, 2005 700+ words
...aromatase inhibitor, either alone or after tamoxifen therapy, is better than tamoxifen alone for the long-term prevention of breast...survival in postmenopausal women, compared with tamoxifen as a single agent. Consequently, "tamoxifen...
- Tamoxifen and the uterus: women given this drug need careful assessment....
- Magazine article from: British Medical Journal Neven, P. Muylder, X. de Belle, Y. van Campo, R. Vanderick, G. November 19, 1994 700+ words
The effects of tamoxifen on the endometrium have caused concern...5] In most women treated with tamoxifen the endometrium remains atrophic...binding profain-3 are important in tamoxifen's uterotrophic effect.[7] In...
- Tamoxifen (Systemic).
- USP DI-Volume II, Advice for the Patient: Drug Information in Lay Language January 1, 1997 700+ words
Some commonly used brand names are: In the U.S. -- Nolvadex In Canada -- Alpha-Tamoxifen Med Tamoxifen Nolvadex Nolvadex-D Novo-Tamoxifen Tamofen Tamone Tamoplex Description Tamoxifen (ta-MOX-i-fen) is a medicine that blocks...
- Tamoxifen benefit lasts 10 years, new data show: the relative risk of breast...
- Magazine article from: Clinical Psychiatry News Jancin, Bruce February 1, 2007 700+ words
...up from a landmark clinical trial of tamoxifen for breast cancer prevention indicates...important for the overall evaluation of tamoxifen in prevention. If you get the same benefit...cancer were randomized to 5 years of daily tamoxifen or placebo. Such a placebo-controlled...
Source: HighBeam Research, Tamoxifen Use Not Associated With Decreased Sexual Functioning Or...