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Ethnicity, Genes May Be Factor in Premenopausal Occurrence.
2001 APR 19 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols. staff medical writer -- Ethnicity and genetic changes may predispose women to an increased risk for premenopausal breast cancer.
Researchers at the University of Toronto in Canada suggest African-American women on oral contraceptives may experience genetic alterations that increase circulating plasma levels of insulin-like growth factor (IGF)-I, a substance that sustains the growth of new tumors.
"The relative risk of breast cancer associated with oral contraceptive use has been reported to be higher for African-American women than for white women. African-American women also have a higher incidence of premenopausal breast cancer than white women," H. Jernstrom et al. said in Molecular Genetics and Metabolism.
Researchers also noted that IGF-I levels vary among races, and have been linked to the onset of premenopausal breast cancer.
The Canadian study included 503 women of different ethnicities who had never been pregnant before. In addition to filling out questionnaires, the women were tested for plasma levels of IGF-I and genetic changes linked to IGF-I production.
"Black women had significantly higher mean IGF-I levels than white women (after adjusting for age and oral contraceptive use)," Jernstrom et al. reported.
Although white women who took oral ...
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