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Fulvestrant Targets And Degrades Estrogen Receptor.(Faslodex, breast cancer)
2001 APR 19 - (NewsRx.com & NewsRx.net) -- AstraZeneca announced on March 29, 2001, that it submitted a new drug application (NDA) requesting Priority Review with the U.S. Food and Drug Administration (FDA) for Faslodex[TM] (fulvestrant) for treatment of locally advanced or metastatic breast cancer in postmenopausal women who have previously progressed following hormonal therapy.
Faslodex is characterized as an estrogen receptor downregulator and works differently than other hormonal breast cancer drugs in that it targets and degrades the estrogen receptor. Currently, advanced breast cancer patients whose tumors have been shown to use hormones to grow, are given drugs like tamoxifen that act by blocking the estrogen receptor or aromatase inhibitors that lessen the amount of estrogen in a woman's body. After a period of time, tumors can become resistant to these types of treatments and cancer may progress.
The FDA submission was based on data from ...
- FASLODEX(R) (Fulvestrant) Added to Nationally Recognized Breast Cancer...
- Press release article from: PR Newswire April 24, 2003 700+ words
...Guidelines in Oncology for Breast Cancer." FASLODEX is included in their...postmenopausal women with breast cancer, treatment with FASLODEX showed a decrease...estrogen receptors in breast cancer cells. FASLODEX is administered as...
- New Breakthrough Treatment For Breast Cancer, Faslodex Launched In UK Today.
- Press release article from: PR Newswire May 12, 2004 700+ words
...provides new choice for women with advanced breast cancer. A new breast cancer drug, Faslodex(TM) (fulvestrant), was launched today...quality of life for women with advanced breast cancer. Faslodex is a long-acting, once-monthly injection...
- New Clinical Trial of FASLODEX(R) (Fulvestrant) Seeks to Identify Additional...
- Press release article from: PR Newswire August 6, 2003 700+ words
...effectiveness of FASLODEX in patients with advanced breast cancer whose disease has...postmenopausal women with breast cancer, treatment with FASLODEX showed a decrease...estrogen receptors in breast cancer cells. FASLODEX is administered...
- New Data Reported on FASLODEX(R) (Fulvestrant) Injection in Postmenopausal...
- Press release article from: PR Newswire December 11, 2004 700+ words
...treatment with FASLODEX in 67 postmenopausal...women with advanced breast cancer who had previously...treatment with FASLODEX in 77 postmenopausal...women with advanced breast cancer, who had disease...as tamoxifen. FASLODEX is the only approved...therapy for advanced ...
- Survival Analysis Supports Use of FASLODEX as an Effective Option for...
- Press release article from: PR Newswire December 5, 2003 700+ words
...FDA) approved FASLODEX in 2002 for the...positive metastatic breast cancer in postmenopausal...as tamoxifen. FASLODEX is the only approved...therapy for advanced breast cancer administered as...positive metastatic breast cancer. The trial, called...Evaluation of ...
- FASLODEX AS EFFECTIVE AS ARIMIDEX IN ADVANCED BREAST CANCER.
- News wire article from: AsiaPulse News December 8, 2003 700+ words
...women with advanced breast cancer treated with the...receptor antagonist, 'Faslodex', have comparable...reminders of their breast cancer. The data confirm that 'Faslodex' is a valuable...positive metastatic breast cancer in post-menopausal...
- Clinical potential of Faslodex established in Phase III data.(breast cancer)
- Magazine article from: Women's Health Weekly October 31, 2002 700+ words
...resistant advanced breast cancer, confirming that Faslodex works in a...receptor, Faslodex targets and...receptors in breast cancer cells. In...Henderson, a noted breast cancer expert from...concludes that Faslodex is one of a...
- Analysis shows Faslodex effective in treating metastatic breast cancer.
- Newspaper article from: Pharma Business Week December 29, 2003 700+ words
...FDA) approved Faslodex in 2002 for the...positive metastatic breast cancer in postmenopausal...as tamoxifen. Faslodex is the only approved...therapy for advanced breast cancer administered as...positive metastatic breast cancer. The trial, called...Evaluation of ...
