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Hepatitis E Carries Highest Risk For Morbidity, Mortality In Pregnancy.
2001 APR 19 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer - A study of acute viral hepatitis in pregnant women shows hepatitis E virus (HEV) causes the most morbidity and mortality in this population.
Previous studies have shown HEV infections, though mild in the general population, cause fulminant hepatic failure and even death in pregnant females. An epidemiological study of acute hepatitis in women in India sheds more light on the impact of HEV infections during pregnancy.
The study's lead author, S.P.B. Jaiswal, and associates at Choithram Hospital and Research Center tested the serum of 273 women with acute viral hepatitis for hepatitis viruses A, B, C, D (HAV, HBV, HCV, HBD), and HEV. Of the study group, 127 women were pregnant. Eighty three of the pregnant women exhibited signs of acute viral hepatitis, and 44 had fulminant hepatic failure, an illness characterized by the rapid loss of liver function.
In contrast, only 17 and 129 of the 146 non-pregnant women had fulminant hepatic failure or acute viral hepatitis, respectively.
"Among the acute viral hepatitis pregnant females, 73 (57.5%) had HEV infection. Fifty-eight percent of the HEV-infected pregnant females were associated with fulminant hepatic failure," reported Jaiswal et al.
Prevalence of HEV in non-pregnant women was 46%, and the ...
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