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Gene Defect In Toxin Clearance Associated With Pre-Eclampsia.
2001 APR 19 - (NewsRx.com & NewsRx.net) -- A defect in the gene responsible for producing an enzyme that clears toxic compounds in the body may increase the risk of pre-eclampsia, shows research in the Journal of Medical Genetics.
Pre-eclampsia occurs only during pregnancy, and usually during the later part. Characterized by high blood pressure, swelling, and protein in the urine, it affects both mother and baby. Pre eclampsia progresses rapidly if left untreated, and can be fatal. Around one in 20 pregnancies is affected.
Dr. Eric Steegers and colleagues at University Hospital Nijmegen, The Netherlands, looked for genetic defects in the blood samples of 183 women who were not pregnant, but who had a history of pre-eclampsia, and 151 healthy women. The women were roughly the same age. The researchers focused on the gene responsible for the production of the enzyme epoxide hydrolase, which has a vital role in breaking down toxic compounds taken in, or produced by, the body. They looked for defects in two sections of the gene: exon 3 and exon 4. An exon 3 defect exaggerates the levels of epoxide hydrolase in the body.
Women with a history of pre-eclampsia were almost twice as likely to carry the exon 3 defect as ...
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Source: HighBeam Research, Gene Defect In Toxin Clearance Associated With Pre-Eclampsia.