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Rabies Virus Vectors Induce T-Cell Response.(Brief Article)
2001 APR 25 - (NewsRx.com & NewsRx.net) --
by Michael Greer, staff medical writer - HIV vectors based on the rabies virus induce robust T-cell responses, suggesting that such vectors may be useful in developing an HIV vaccine, researchers report.
"Novel viral vectors that are able to induce both strong and long-lasting immune responses may be required as effective vaccines for [HIV 1] infection," James P. McGettigan and colleagues explained in the Journal of Virology.
McGettigan et al. found that vectors based on the rabies virus provoke just such a response in mice.
The researchers had previously shown that rabies viruses modified to express HIV envelope proteins could be effectively used for B-cell priming. Such recombinant rabies viruses can also elicit a strong cytotoxic T lymphocyte (CTL) response, they said.
A single injection with this vector provoked a robust and persistent CTL response, study data showed. This immune response was specifically targeted at the HIV envelope protein expressed by the recombinant rabies vector.
Vector-induced CTL responses were able to destroy cells expressing envelope proteins from both homologous and heterologous strains of HIV ("Rabies virus-based vectors expressing human immunodeficiency virus type 1 (HIV 1) envelope protein induce a ...
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Source: HighBeam Research, Rabies Virus Vectors Induce T-Cell Response.(Brief Article)