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DNA Vaccination Through Skin Attractive But Not Yet Feasible.(Brief Article)
2001 APR 25 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Although researchers have made great strides in the effort to find safe, efficient methods to deliver DNA vaccines or drugs to the skin, work still needs to be done, say scientists working in Belgium.
V. Preat and colleagues characterized the state of DNA delivery to the skin and outlined remaining challenges in their report appearing in STP Pharma Sciences.
"The skin is an attractive site for the delivery of nucleic acid-based drugs for the treatment of topical and/or systemic diseases as well as for DNA immunization," said Preat et al. "However, due to the barrier properties of the skin, the penetration of nucleic acids in or across the skin is limited."
Oligonucleotides have been delivered across the skin using iontophoresis, which generated potentially therapeutic concentrations of oligonucleotides to hair follicles and keratinocytes, Preat and team reported. Other methods include dermal injection; topical application of naked DNA, DNA-lipid complexes, or viral vectors; and particle bombardment, puncturing, or electroporation of plasmid DNA.
These methods have yielded variable protein expression in the skin and/or the serum ("Topical delivery of nucleic acids in the skin," STP Pharma Sciences, 2001;11(1):57-68).
"The remaining challenges to address for optimal in vivo gene delivery in the skin are i) ...
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