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Clinical Trials Appropriate For High-Risk Cohorts In U.S.(Brief Article)
2001 APR 25 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A prospective study of human immunodeficiency virus type 1 (HIV-1) incidence among high-risk cohorts lends support to the idea that HIV-1 vaccine trials would be appropriate and welcomed in these populations in the United States.
"Questions exist about whether testing of preventive HIV-1 vaccines, which will require rapid recruitment and retention of cohorts with high HIV-1 seroincidence, is feasible in the United States," said G.R. Seage, III, and colleagues in the HIVNET Vaccine Preparedness Study group at the Harvard School of Public Health.
They conducted a prospective cohort study in 1995-1997 among 4,892 people at high risk for HIV infection in nine U.S. cities.
Of the 88% of study participants responding, 90 had HIV-1 infection, for an overall rate of 1.31/100 person-years. Men who had sex with men were at greatest risk (1.55/100 person-years), followed by male intravenous (IV) drug users (0.38/100 person-years), female IV drug users (1.24/100 person-years), and heterosexual women (01.13/100 person-years), reported Seage et al.
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