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Telomerase Activity In Peripheral Blood Mononuclear Cells Linked To Severity.(of systemic connective tissue diseases)
2001 APR 12 - (NewsRx.com & NewsRx.net) -- by Michael Greer, staff medical writer - Telomerase activity in peripheral blood mononuclear cells (PBMCs) is linked to the presence and severity of systemic connective tissue diseases such as lupus and Sjogren's syndrome, a new study reports.
"Telomerase activity has been detected in a large number of cancers, as well as human germline tissue, but is absent in most normal somatic tissue," Y. Katayama and colleagues wrote in the Journal of Rheumatology. "It has been reported that telomerase is also expressed at a low level in normal peripheral blood lymphocytes and that its activity is increased by antigen processing."
Katayama et al. confirmed that detectable telomerase activity was present in many patients suffering from systemic connective tissue disorders, and that patients with more advanced disease were more likely to demonstrate such activity.
Telomerase, an enzyme involved in DNA replication, was found to be active in 64.7% of systemic lupus patients and 63.6% of patients with mixed connective tissue disease, study data showed. The researchers also found similar activity in 54.5% of patients suffering from primary Sjogren's syndrome and in 44.4% of systemic sclerosis patients.
The degree of telomerase activity was significantly and strongly correlated with the ...
- Telomerase Activity In Peripheral Blood Mononuclear Cells Linked To Severity.
- Newspaper article from: Blood Weekly April 12, 2001 700+ words
...detectable telomerase activity was present...from systemic connective tissue disorders...glands ("Telomerase activity in peripheral...of systemic connective tissue diseases...include: * Telomerase activity is often present...with systemic connective ...
- Telomerase activity is related to the progression and invasion of bone cancer.
- Newspaper article from: Cancer Vaccine Week March 22, 2004 700+ words
...NewsRx.net) -- Activation of telomerase activity in pediatric bone cancer indicates...Pediatric Research, "The presence of telomerase activity has been analyzed in almost all...studies that focus on the presence of telomerase activity in bone tumors, and most of them...
- High Telomerase Activity Correlates with Extent of Malignancy.(in...
- Newspaper article from: Cancer Weekly May 2, 2000 700+ words
...2000 MAY 2 - (NewsRx.com) -- Telomerase activity may predict the extent of malignancy...hepatocellular carcinoma ("The role of telomerase activity in hepatocellular carcinoma...752). Investigators determined telomerase activity by using a repeat amplification...
- High Telomerase Activity Correlates with Extent of Malignancy.
- Newspaper article from: Hepatitis Weekly May 1, 2000 700+ words
...2000 MAY 1 - (NewsRx.com) -- Telomerase activity may predict the extent of malignancy...hepatocellular carcinoma ("The role of telomerase activity in hepatocellular carcinoma...752). Investigators determined telomerase activity by using a repeat amplification...
- Measuring Telomerase Activity May Have Prognostic and Diagnostic Applications.
- Newspaper article from: Cancer Weekly September 19, 2000 700+ words
...determined by measuring levels of telomerase activity in biopsy specimens, researchers...reported finding detectable levels of telomerase activity in biopsy specimens or surgically...observed significantly higher levels of telomerase activity in three of 15 mild dysplasia specimens...
- Loss of telomerase activity may be a prognostic marker in lung carcinomas.
- Newspaper article from: Cancer Weekly September 30, 2003 700+ words
...amp; NewsRx.net) -- Loss of telomerase activity may be a prognostic marker in lung...cancer and immortal cells exhibit telomerase activity that stabilizes telomere lengths...clinicopathological relationship between telomerase activity and telomerase reverse transcriptase...
- Telomerase activity and COX-2 may be potential markers for certain cancers.
- Newspaper article from: Science Letter October 19, 2004 700+ words
...studied, and researchers found telomerase activity and COX-2 as potential markers...to utilize recent markers such as telomerase activity and cyclooxygenase-2 (COX-2...expression of p53 protein, COX-2 and telomerase activity," according to the study. "Higher...
- p16 Plasmids control telomerase activity in human gliomas.
- Newspaper article from: Drug Week June 25, 2004 700+ words
...net) -- p16 Plasmids control telomerase activity in human gliomas. According to...have been noted as regulators of telomerase activity. However, the link between telomerase...p16, as well as p53, suppresses telomerase activity through transcriptional regulation...
