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Vaccine Incorporating Lactobacillus Carrier Protects Mice From Lethal Challenge.(Brief Article)
2001 APR 18 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Immunizing mice with live Lactobacillus plantarum carrying a tetanus toxin protected them from a subsequent lethal injection of tetanus, say researchers working in France.
C. Grangett and colleagues at Institut Pasteur wanted to test the proposal that using live microorganisms to carry antigens could elicit immune responses that translated to disease protection. They used Lactobacillus bacteria to deliver tetanus vaccine because of their established safety profile in humans and their high immunogenicity.
"To determine whether an immune response could be elicited by intranasal delivery of recombinant lactobacilli, a L. plantarum strain of human origin (NCIMB8826) was selected as the expression host," reported Grangett and team. "Cytoplasmic production of the 47-kDa fragment C of tetanus toxin (TTFC) was achieved at different levels depending on the plasmid construct."
Although the researchers found no difference in immune response of mice immunized with live or mitomycin-C-treated bacteria, only the live bacteria, together with the highest antigen dose, were able to protect mice from a lethal challenge of tetanus.
Furthermore, mice receiving a double dose of live bacteria at each administration showed higher immunoglobulin A and T-cell responses, the researchers said ("Mucosal immune ...
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