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New DNA Vaccine Stimulates Antibody Response In Mice.(Brief Article)
2001 APR 18 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A DNA vaccine containing a peptide sequence that closely mimics a Streptococcus pneumoniae serotype may offer a useful alternative to current S. pneumoniae vaccines.
The current polysaccharide vaccine is ineffective in the elderly and children younger than two, while newer conjugate vaccines also are limited in some populations, said G.B. Lesinski and colleagues at the Medical College of Ohio. They proposed a DNA vaccine to circumvent these problems and address the significant morbidity and mortality caused by S. pneumoniae worldwide.
"We have defined a peptide sequence (pep4) that mimics the S. pneumoniae serotype 4 capsular polysaccharide (PPS4) using a monoclonal antibody to PPS4 (mAb4) and phage display library," explained Lesinski and team. "Pep4 was synthesized, complexed to proteosomes, and used to immunize mice."
The researchers followed up this effort, which elicited anti-PPS4 immune response in immunized mice, with development of a PPS4-DNA vaccine made cloning an oligodeoxynucleotide encoding pep4 into the HBcAg vector.
Mice injected with the PPS4-DNA vaccine produced an anti-PPS4 antibody response significantly higher than control ...
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Source: HighBeam Research, New DNA Vaccine Stimulates Antibody Response In Mice.(Brief Article)