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Enterotoxin Vaccine Protects Against Intestinal Parasite.(Brief Article)
2001 APR 18 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A mutated, nontoxic, heat-labile enterotoxin appears to be an effective carrier for Toxoplasma gondii vaccine in mice.
Animals vaccinated with two versions of the vaccine showed a decrease in cerebral tumors caused by challenge with T. gondii.
C. Bonenfant and colleagues wanted to test LTR72 and LTK63, two nontoxic mutant enterotoxins, for vaccine delivery, proposing that their strong mucosal activities would induce a long-lasting immunogenic response.
When they vaccinated mice with LTR72 and LTK63 plus T. gondii SAG1 protein, Bonenfant et al. observed high-level protection in terms of reduced cerebral tumor load following challenge with the 76K strain of T. gondii.
Both vaccines also induced strong systemic and mucosal immune responses, but only cells vaccinated with LTR72 responded to re-stimulation with a T. gondii lysate antigen in vitro, reported the researchers ("Intranasal immunization with SAG1 and nontoxic mutant heat-labile enterotoxins protects mice against Toxoplasma gondii," Infection ...
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