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VraA Protein Vaccine Offers Partial Immunity.(Brief Article)
2001 APR 18 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - An antigen associated with Borrelia burgdorferi strain B31 is a promising candidate for vaccination against Lyme disease, say researchers working in the United States.
M. Labandeira-Rey and colleagues at Texas A&M University named the antigen VraA for virulent strain-associated repetitive antigen A, one of seven B. burgdorferi B31 antigens isolated in previous studies.
"The VraA locus (designated BBI16 by The Institute for Genomic Research) maps to one of the 28-kb linear plasmids designated 1p28-43 that is not present in noninfectious strain B31 isolates," explained Labandeira-Rey and associates. "Subsequent polymerase chain reaction analysis of clonal isolates of B. burgdorferi B31 from infected mouse skin revealed a clone that lacked only 1p28-4."
Further analysis with Southern and Western blots showed that 1p28-4 and VraA proteins, respectively, were missing from this clone.
The researchers characterized VraA as follows:
* It is a surface-exposed protein
- VraA Protein Vaccine Offers Partial Immunity.
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