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HPV 16 Vaccine Effective, Well-Tolerated In Humans.(Brief Article)
2001 APR 18 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Immunization with a papillomavirus virus-like particle (VLP) vaccine composed of L1, a major structural viral protein, is safe and highly effective in humans, researchers report.
Earlier studies showed that the vaccine was successful in animals challenged with human papillomavirus (HPV) 16 and this trial in humans with HPV confirms those findings.
C.D. Harro and colleagues at the U.S. National Institutes of Health evaluated the HPV 16 L1 VLP vaccine in adults in a double-blind, placebo-controlled, dose-escalation trial. Subjects received placebo or various formulations of vaccine (10 (micro)g or 50 (micro)g doses, without adjuvant or with alum or MF59 as adjuvants) in three doses.
All six subjects with HPV 16 who received the HPV 16 L1 VLP vaccine seroconverted, and all tolerated the vaccine well, reported Harro et al.
The pre-vaccination geometric mean antibody titer for the six subjects with HPV was 202, as measured by enzyme-linked immunosorbent assay (ELISA). With the higher dose, one month after the third injection, titers for the various formulations were as follows:
* 10,240 without adjuvant
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Source: HighBeam Research, HPV 16 Vaccine Effective, Well-Tolerated In Humans.(Brief Article)