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Oral Vaccine Development Gets A Shot In The Arm From Chitosan Microparticles.(Brief Article)
2001 APR 18 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Microparticles that can entrap vaccine and then release it in the gastrointestinal tract represent an exciting potential carrier for oral immunization, say researchers working in The Netherlands.
Oral vaccination is highly desirable in terms of cost, safety, and appeal, but until now, oral delivery has suffered from low bioavailability and a lack of uptake in intestinal lymph tissues.
I.M. van der Lubben and colleagues proposed that chitosan microparticles offer a unique vehicle for vaccine delivery because they are small enough to be absorbed by Peyer's patches in mice and bioavailable enough to release vaccine during digestion. Their findings were published in Biomaterials.
van der Lubben and team prepared positively charged chitosan microparticles that were 4.3 +/- 0.7 (micro)m in size, small enough to be absorbed by the M cells of Peyer's patches. Confocal laser scanning microscopy (CLSM) revealed that the microparticles were able to entrap the model antigen ovalbumin, at a capacity of about 40%.
The biodegradable chitosan microparticles also could retain about 90% of entrapped ovalbumin, which, in theory, would be released upon intracellular digestion in the Peyer's patches, van der Lubben and associates reported ("Chitosan microparticles for oral vaccination: Preparation, characterization and preliminary in ...
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Source: HighBeam Research, Oral Vaccine Development Gets A Shot In The Arm From Chitosan...