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Long-Term ERT Associated With Increased Risk Of Ovarian Cancer Death Among Postmenopausal Women.(estrogen replacement therapy )
2001 APR 5 - (NewsRx.com & NewsRx.net) -- In a new study, women who used postmenopausal estrogens for 10 years or more were found to be at substantially increased risk of fatal ovarian cancer that persisted for many years after estrogen replacement therapy was stopped.
The association was reported in the March 21, 2001, issue of the Journal of the American Medical Association.
Carmen Rodriguez, MD, MPH, and colleagues with the American Cancer Society, Atlanta, Georgia, followed 211,581 postmenopausal women from 1982 to 1996 to examine the association between the use of postmenopausal estrogen replacement therapy (ERT) and ovarian cancer mortality.
"This large prospective study supports the hypothesis that ERT increases the risk of fatal ovarian cancer. The association was related to both duration and recency of hormone use," Rodriguez et al. found.
According to background information cited in the article, postmenopausal estrogen use is associated with an increased risk of endometrial and breast cancer (only when used for a long period), two hormone-related cancers. The effect of postmenopausal estrogen use on ovarian cancer is not established.
This study population included women who enrolled in the American Cancer Society's Cancer Prevention Study II in 1982 and had no history of cancer, hysterectomy, or ovarian surgery. A total 46,260 (22%) of the women in the study population had used ERT, including 11,024 who were users at baseline and 35,236 who were former users. A total of 944 ovarian cancer deaths were recorded in 14 years of follow-up through December 1996.
"In this population, postmenopausal estrogen use for 10 or more years was associated with increased risk of ovarian cancer mortality that persisted up to 29 years after cessation of use," the authors wrote. "The risk of death was approximately doubled in women who had used estrogens for 10 or more years within the 15 years prior to enrollment."
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Source: HighBeam Research, Long-Term ERT Associated With Increased Risk Of Ovarian Cancer Death...