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New Blood Vessel Growth Related To Tumor Recurrence After Dormancy.(breast cancer recurrence)
2001 MAR 29 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer - Scientists in Italy suggest that breast cancer patients with substantial blood vessel growth in their primary tumors have a greater chance for tumor recurrence several years after receiving adjuvant chemotherapy
Angiogenesis, the growth of new blood vessels, increases the risk for tumor metastasis and recurrence in breast cancer patients. Researchers have developed a rating system that quantifies tumor vessel growth in breast cancer tumors. The data from that system significantly correlate angiogenesis with recurrent breast cancer and metastasis after lengthy periods of tumor dormancy.
"We determined the vascular index in a series of 190 women operated of node-positive invasive breast cancer treated with adjuvant chemotherapy (CMF [cyclophosphamide-methotrexate-fluorouracil] schedule) and we studied the relationship between vascularity of primary tumors with the behavior in time of metastasis," said G. Gasparini et al. of Azienda Osped San Filippo Neri in Rome.
Over the course of the follow-up period, 80 patients developed tumor recurrences. Recurrence peaked at the 20th and 60th months after primary treatments ("Angiogenesis sustains tumor dormancy in patients with breast cancer treated with adjuvant therapy," Breast Cancer Research and Treatment, 2001;65(1):71-75).
Using linear modeling, researchers identified factors commonly associated ...
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