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Intensified Chemotherapy/Stem Cell Treatment May Not Improve Survival.(of metastatic breast cancer)
2001 MAR 29 - (NewsRx.com & NewsRx.net) -- by Michael Greer, staff medical writer - Early intensification of high-dose chemotherapy (HDCT) with stem cell support seems to have little impact on metastatic breast cancer.
Although many researchers suspect that early dose intensification should produce better results than late intensification, the reports from "randomized trials comparing standard- and high-dose chemotherapy with ASCT [autologous stem cell transplantation] are still controversial," according to Andreas Schneeweiss and colleagues.
Despite improving initial complete remission (CR) rates, Schneeweiss et al. found that double- and triple-dose HDCT (D- and T-HDCT) had no significant effect on the median expected survival of metastatic breast cancer patients. Both regimens resulted in median overall survival times of 24.5 months, similar to the roughly two years expected survival of patients treated with conventional HDCT, study data showed.
While they noted that improved CR frequency may yet translate into improved long-term survival, Schneeweiss et al. said that dose intensifications, which often lead to increased toxicity and lengthened hospital stays, should be avoided if they lack tangible benefits.
The researchers found ...
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