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Intestinal Worms May Lower Efficacy Of BCG Vaccine.(Brief Article)
2001 APR 11 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Parasites endemic in some parts of the world may have a detrimental effect on tuberculosis immunity, according to a new report in Clinical and Experimental Immunology.
Infestation with helminth worms appears to lower immune response to the purified protein derivative (PPD) test, said D. Elias and colleagues working in Sweden.
People with helminth infection were randomized to receive treatment with albendazole or placebo. The treated group showed much higher T-cell response and interferon-gamma production by peripheral blood mononuclear cells to PPD testing than the untreated group, reported the researchers.
Patients with negative skin tests from both groups were given the bacillus Calmette-Guerin (BCG) vaccine and later, another PPD. BCG vaccination boosted immune response in the treated, but not untreated group ("Effect of deworming on human T-cell responses to mycobacterial antigens in helminth-exposed individuals before and after bacille Calmette-Guerin (BCG) ...
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...developed chronic anterior uveitis after receiving an intradermal BCG vaccine. The girl, who had family history of uveitis and rheumatoid arthritis, received a routine BCG vaccine [dosage not stated] and, 10 days later, reported bilateral...
Source: HighBeam Research, Intestinal Worms May Lower Efficacy Of BCG Vaccine.(Brief Article)