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CD40-Stimulated Dendritic Cells Boost Immunity, But Not Disease Resistance.(Brief Article)
2001 APR 11 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Using dendritic cells stimulated with the cytokine CD40 to vaccinate against tuberculosis enhances immune response to the disease, but does not prevent lung infection, researchers have found.
Caroline Demangel and colleagues in Australia proposed that a vaccination strategy optimizing interleukin 12 (IL-12) production by antigen-presenting cells (APCs) could stimulate immunity to TB infection.
"Since dendritic cells (DC) are the critical APC for activation of CD4(+) and CD8(+) T cells, we examined whether stimulation of Mycobacterium bovis bacillus Calmette-Guerin (BCG)-infected DC via CD40 increased their ability to generate Th1-oriented cellular immune responses," reported Demangel and associates.
The researchers stimulated CD40 signaling in dendritic cells by incubating them with CD40 antibody, which was maintained after infection with BCG. This CD40-stimulated, BCG-infected DC produced bioactive IL-12 and gamma interferon (IFN-gamma)-producing T cells in vitro ("Stimulation of dendritic cells via CD40 enhances immune responses to Mycobacterium tuberculosis infection," Infection and Immunity, April 2001;69(4):2456-61).
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Source: HighBeam Research, CD40-Stimulated Dendritic Cells Boost Immunity, But Not Disease...