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DNA Vaccine Prevents But Does Not Cure Infection.(Brief Article)
2001 APR 11 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A DNA vaccine combining outer surface proteins (Osp) of Borrelia burgdorferi is able to stimulate antibody protection against future infection with Lyme disease but not to resolve existing infection, report immunologists.
Previous studies had shown that vaccination with OspA could prevent, but not cure infection with Borrelia burgdorferi, while passive transfer of antibodies to OspC could cure infection.
"In the present study, DNA vaccines encoding either the OspC antigen alone or fused to OspA and under the transcriptional control of the human elongation factor 1(alpha) promoter were evaluated for their protective and/or curative potential," said Reinhard Wallich and colleagues.
They found that none of the six vaccines encoding OspC caused enhanced immunity in vivo, but a DNA vaccine encoding a fusion of OspA and OspC caused not only expression of the relevant polypeptide chain in vitro but enhanced immune response in vivo. That enhanced immunity did not, however, translate to cure of the current infection ("DNA vaccines expressing a fusion product of outer surface proteins A and C from Borrelia burgdorferi induce ...
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Source: HighBeam Research, DNA Vaccine Prevents But Does Not Cure Infection.(Brief Article)