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Antibody Response Depends On Dose Of Inactivated Enterotoxigenic E. coli.(Brief Article)
2001 APR 11 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Researchers working in Sweden have developed an oral inactivated Escherichia coli vaccine that boosts circulating antibodies in a dose-dependent manner.
Marianne Jertborn and colleagues report that various preparations of oral inactivated enterotoxigenic E. coli (ETEC) vaccine stimulated immune response in Swedish volunteers who had never been exposed to E. coli.
They vaccinated subjects with cholera toxin B subunit (CTB) and various amounts of formalin-killed whole E. coli bacteria expressing the most prevalent colonization factor antigens (CFAs). After the second dose of vaccine, the majority of volunteers showed significant immunoglobulin A (IgA) antibody-secreting cell (ASC) response against E. coli, reported Jertborn and associates.
They also observed both weaker ASC reactions and lower serum antibody responses to reduced doses of CFA-ETEC bacteria ("Dose-dependent circulating immunoglobulin A antibody-secreting cell and serum antibody responses in Swedish volunteers to an oral inactivated enterotoxigenic Escherichia coli vaccine," Clin Diagn Lab Immunol, March ...
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