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Antibody Reactivity Boosts Virulence.(Brief Article)
2001 APR 11 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Researchers working in the United States say they may have found an answer to the question, "What makes Ebola virus so deadly?"
Antibody reactivity to the virus appears to be critical to its infectivity, which in some strains results in a 100% mortality rate, reported A. Takada and colleagues working at the University of Wisconsin.
"We show that antisera produced by DNA immunization with a plasmid encoding the surface glycoprotein (GP) of the Zaire strain of Ebola virus enhances the infectivity of vesicular stomatitis virus pseudotyped with the GP," said Takada and associates.
Immunization with a less potent form of Ebola, the Reston strain, produced only mild antibody enhancement of virulence, the researchers said.
Heat neutralized the antibody boosting effect but complement system inhibitors encouraged it, they noted ("Infectivity-enhancing antibodies to Ebola virus glycoprotein," Journal of Virology, 2001;75(5):2324-2330).
Takada and team were able to construct an anti-Zaire monoclonal antibody that increased viral potency of Ebola and one that neutralized it. They reasoned that distinct epitopes ...
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Source: HighBeam Research, Antibody Reactivity Boosts Virulence.(Brief Article)