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Unforeseen Role Of Immune Response In Neurological Repair Could Lead To Vaccine.(Brief Article)
2001 APR 11 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Macrophages and T cells can stop the spread of damage after central nervous system injury, report Weizmann Institute of Science researchers.
Immune activity was heretofore considered at best a neutral player in the central nervous system (CNS), and at worst destructive. But now Michal Schwartz and colleagues propose that within strictly controlled conditions, immune response can heal.
"A recent study in our laboratory showed, against all expectations, that macrophages and a particular type of T-cell, by promoting re-growth and reducing the post-traumatic spread of damage in the injured rat optic nerve or spinal cord, have a beneficial effect on the injured CNS," noted Schwartz and associates.
Macrophages can repair cells and specific T cells can reduce the spread of damage in rats with CNS injury, Schwartz and team found.
Spontaneous generation of these immune activities following injury, however, is limited. Immune response must be manipulated under strictly controlled conditions for effectiveness ("Beneficial immune activity after CNS injury: Prospects for vaccination," Journal of Neuroimmunology, 2001;113(2):185-192).
"It thus appears that (i) a stress ...
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