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Adapted Human Strain Discovered To Induce Strong Immune Response In Mice.(Brief Article)
2001 APR 11 - (NewsRx.com & NewsRx.net) --
A group of scientists from Emory University and the U.S. Centers for Disease Control and Prevention (CDC) has discovered that a mouse strain of Ebola virus, adapted from a human strain, induces a strong T-cell immune response, despite the belief of some scientists that the lethal effects of Ebola are due to virus-caused suppression of the immune system.
This new information about the immune response to Ebola could be an important step in developing an effective vaccine against the disease.
Ebola is an RNA virus that causes a severe hemorrhagic fever in humans and non-human primates, beginning within a few days of infection, with mortality of 50% to 80% in as little as one week. The mouse-adapted strain tested by the Emory and CDC scientists produces 100% mortality in mice within six to eight days following intraperitoneal injection of a low dose of virus.
Using markers of T-cell activation, the researchers detected a high frequency of activated CD4 and CD8 T cells in mice beginning as early as four days post-infection. In addition, the scientists detected high levels of the cytokine interferon gamma in the spleen, liver, and serum. Cytokines are proteins produced by T cells that prevent the growth of viruses and make cells resistant to viral infection.
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