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P40 Adjuvant Has Potential For Anti-Tumor Vaccine.(Brief Article)
2001 APR 11 - (NewsRx.com & NewsRx.net) --
N.R. Saltmarsh, staff medical writer - A Klebsiella pneumoniae membrane protein appears to be a useful adjuvant for immune stimulation with peptide vaccines, say researchers working in France.
I. Miconnet and colleagues at the University of Lausanne noted that the potential of tumor antigens as vaccines has encouraged a search for efficient adjuvants and delivery systems, especially for peptide-based vaccinations.
"We investigated the adjuvant potential of the recombinant 40-kDa outer membrane protein of Klebsellia pneumoniae (P40) for specific CTL induction," reported Miconnet and team.
They combined P40 with two peptide antigens: the HLA-A*0201-restricted decapeptide Melan-A(26-35) substituted at position 2 and the K(b)-restricted tyrosinase-related protein 2(181-188) T-cell epitope.
Both peptide vaccines were able to induce immune response in HLA-A*0201/K(b) transgenic mice, in proportion to the amount of P40 used. The tyrosinase-related protein 2(181-188) peptide was associated with tumor protection in two ...
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Source: HighBeam Research, P40 Adjuvant Has Potential For Anti-Tumor Vaccine.(Brief Article)