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Tumor Cells In Bone Marrow Linked To Early Relapse, Death.(ovarian cancer)
2001 MAR 22 - (NewsRx.com & NewsRx.net) -- by N.R. Saltmarsh, staff medical writer -- Identification of tumor cells in the bone marrow of patients with Stage I or II ovarian cancer is strongly linked with early relapse and death from the disease.
S. Braun and colleagues in Germany had noted the discrepancy between autopsy findings of extra-abdominal metastasis in ovarian cancer patients and the widely held belief that ovarian cancer confines itself to abdominal structures.
They proposed to identify metastatic disease in bone marrow of early-stage patients with a monoclonal antibody tracer, and to clarify whether marrow tumor cells could predict disease prognosis.
"Autopsy studies reveal a much higher rate of occult metastasis [than is typically observed], indicating that extraperitoneal spread occurs with much greater frequency than previously appreciated," explained Braun and associates. "Consequently, we investigated the incidence of early hematogenous dissemination and its association with distant disease-free and overall survival."
Using the anti-cytokeratin (CK) antibody A45-B/B3, researchers investigated the frequency of CK-positive tumor cells in bone marrow samples of 108 patients and analyzed their effect on prognosis ("Occult tumor cells in bone marrow of patients with locoregionally restricted ovarian cancer predict early distant metastatic relapse," Journal of Clinical Oncology, 2001;19(2):368-375).
Tumor cells were detected in 30% of patients. At a median follow-up of 45 months, presence of tumor cells was associated with distant metastases and death. Because the ...
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Source: HighBeam Research, Tumor Cells In Bone Marrow Linked To Early Relapse, Death.(ovarian...