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Clinical Trial Will Compare Effectiveness Of Chemotherapy Combinations.(ovarian cancer )
2001 MAR 22- (NewsRx.com & NewsRx.net) -- An international clinical study to evaluate new treatments for women with ovarian cancer is now open in the U.S., with plans for activation in the United Kingdom, Italy, Scandinavia, Australia, New Zealand, and other countries.
This randomized study will compare the overall effectiveness of the standard treatment (a combination of paclitaxel and carboplatin) for ovarian cancer with recently developed chemotherapy combinations incorporating newer drugs.
Michael A. Bookman, MD, a medical oncologist at Fox Chase Cancer Center in Philadelphia, Pennsylvania, is the lead investigator for this treatment study. It was developed by the Gynecologic Oncology Group, an organization dedicated to clinical research in gynecologic cancer, in collaboration with an international panel of experts and with assistance from the pharmaceutical industry. The study is sponsored by the U.S. National Cancer Institute.
The primary objective of the international study is to compare overall survival and progression free survival of each of the four experimental arms with the standard chemotherapy treatment of paclitaxel and carboplatin.
"Currently, surgery and chemotherapy for ovarian cancer is effective, but long-term cure is uncommon," said Bookman. "In this study, we hope to determine if adding any one of three promising drugs to the standard treatment will improve the effectiveness."
The drugs that will be studied are topotecan, gemcitabine, and liposomal doxorubicin (Doxil). "Each of these drugs has the ability to directly enhance the activity of carboplatin, which remains the single best drug available to treat ovarian cancer," Bookman added. "In addition, these drugs are already used individually to treat recurrent ovarian cancer, and have good activity in that setting."
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Source: HighBeam Research, Clinical Trial Will Compare Effectiveness Of Chemotherapy...