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Nasal Vaccine Against Human Papillomavirus May Prevent Transmission.

Women's Health Weekly

| March 22, 2001 | Saltmarsh, N.R. | COPYRIGHT 2001 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2001 MAR 22 - (MewsRx.com & NewsRx.net) -- by N.R. Saltmarsh, staff medical writer -- A vaccine that inhibits the growth of human papillomavirus 16 (HPV 16) in mice may ultimately be used to help women stimulate their own immune systems to fight off the infection that causes cervical cancer.

Researchers have theorized that some women are naturally able to resist infection with HPV16 with the help of anti-HPV 16-specific antibodies, though no adequate experimental model exists to test the theory.

"Induction of HPV 16-specific cell-mediated immunity in the genital mucosa could improve the efficacy of a vaccine and a mucosal route of immunization might be necessary to do so," suggested V. Revaz and colleagues.

Previous studies have shown that systemic immunization of mice with HPV16 virus-like particles (VLPs) protects them from subsequent challenge with the virus. In this experiment, researchers used an intranasal vaccine ("Mucosal vaccination with a recombinant Salmonella typhimurium expressing human papillornavirus type 16 (HPV16) L1 virus-like particles (VLPs) or HPV 16VLPs purified from insect cells inhibits the growth of HPV 16-expressing tumor cells in ...

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