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Study Ties Weight Loss In Female AD Patients To APOE Allele.(Alzheimer's disease)
2001 MAR 22 - (NewsRx.com & NewsRx.net) -- The allele of the apolipoprotein E gene (APOE), recently determined to be a risk factor for developing Alzheimer's disease, may also be a clue to the unexplained weight loss inherent in Alzheimer's disease, primarily in women.
Researchers studied an association between APOE allele and weight loss in nearly 1,000 patients, of whom 46 had Alzheimer's disease. They looked at weight loss and other health risk factors at baseline and during a follow-up study 3.5 years later.
On average, Alzheimer's disease patients with the APOE allele lost weight, whereas those without it gained weight. Clinically significant weight loss, considered more than 5% loss of weight, occurred remarkably more often in Alzheimer's disease patients, and to a lesser extent in control subjects who were carrying the APOE gene. When women and men were analyzed separately, weight loss was observed only in the women with Alzheimer's and who were carriers of the APOE allele.
Matti Vanhanen, MD, a neuropsychologist with the Kuopio University Hospital in Kuopio, ...
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Source: HighBeam Research, Study Ties Weight Loss In Female AD Patients To APOE...