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Shwartzman Reaction Allows 'Human-Like' TB Course In Mice.(Brief Article)
2001 APR 4 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - By inducing intragranulomatous necrosis in mice with tuberculosis, researchers have developed a more realistic animal model for testing TB therapies.
Unlike human TB, the disease in mice does not involve lung necrosis, so inducing it would render a more accurate disease model, researchers explained.
P.J. Cardona and colleagues in Spain predicted that the Shwartzman reaction might be a mechanism behind the development of intragranulomatous necrosis in human tuberculosis. Thus, 19 days after infecting C57Bl/6 mice aerogenically with a virulent strain of Mycobacterium tuberculosis, the research team inoculated them intranasally with lipopolysaccharide.
Neutrophil infiltration was apparent 24 hours later, followed in 10 days by necrosis in the centers of primary granulomas ("Towards a 'human-like' model of tuberculosis: Intranasal inoculation of LPS induces intragranulomatous lung necrosis in mice infected aerogenically with Mycobacterium tuberculosis," Scandinavian Journal of Immunology, 2001;53(1):65-71).
"These results lend support to the ...
- Shwartzman Reaction Allows 'Human-Like' TB Course In Mice.
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