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Protein-Conjugated Polysaccharide Vaccines More Protective Than Purified Formulation.(Brief Article)
2001 APR 4 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Polysaccharide antigens conjugated to certain proteins offer better protection against pneumococcal infection than the purified polysaccharide vaccine, according to a review study published in Current Opinion in Pediatrics.
M. Ledwith noted that the pressure to develop an effective pneumococcal vaccine has intensified, thanks growing antibiotic resistance and the lack of efficacy and long-term immunity conferred by the purified polysaccharide vaccine.
The vaccine was particularly inadequate for children younger than two, the age group most likely to be affected by Pneumococcus, Ledwith noted ("Pneumococcal conjugate vaccine," Curr Opin Pediatr, 2001;13(1):70-74).
Clinical trials of the polysaccharide-protein conjugate pneumococcal vaccine show it is safe and able to induce strong and rapid immunity to both infection and antigen challenge, Ledwith found. In addition, it may offer protection against otitis media.
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