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Denditric Cell Vaccines Incorporating Myeloma Protein Deemed Feasible.(Brief Article)
2001 APR 4 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - All classes of myeloma protein may be useful for producing dendritic cell (DC) vaccines with potent anti-tumor effects, according to a study published in Experimental Hematology.
Now, researchers working in California have defined optimal laboratory parameters for pulsing dendritic cells with myeloma proteins for potential myeloma vaccine development.
"To optimize antigen pulsing of DCs, we investigated mechanisms of antigen uptake and evaluated various laboratory parameters including class of myeloma protein, antigen exposure time, and DC maturational stage," said A.W. Butch and colleagues.
The researchers generated DCs from blood stem cell cultures of myeloma patients, then measured uptake of myeloma proteins by DCs with flow cytometry ("Dendritic cells derived from multiple myeloma patients efficiently internalize different classes of myeloma protein," Exp Hematol, 2001;29(1):85-92).
Their principal findings were:
* DCs could rapidly internalize immunoglobulin G (IgG), IgA, and free-kappa light chain myeloma proteins
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