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Aerosol Delivery Of Vaccine May Be Ideal For Developing Countries.(Brief Article)
2001 APR 4 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - A powder formulation of measles vaccine would be a practical alternative to injectable vaccine in developing countries.
Measles still carries a high mortality rate in the developing world, and vaccine by injection has its own risks, including decreased stability of the vaccine upon reconstitution and possible infection from contaminated needles, noted Cynthia LiCalsi and colleagues, Dura Pharmaceuticals, San Diego, California. An aerosol delivery system, therefore, would be ideal, they think.
"The first challenge in aerosol formulation development is to produce fine particles without damaging the activity of the virus or inducing physical changes," noted LiCalsi et al.
The researchers micronized live attenuated measles vaccine by jet milling to reduce particle size to 1-5 (micro)m, then blended the particles with an inert carrier for aerosol delivery ("A powder formulation of measles vaccine for aerosol delivery," Vaccine, 2001;19(17-19):2629-2636).
They found no physical changes or reduced viral potency in the jet-milled particles and ...
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