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Double Flu Vaccine Yields Better Antibody Response In Frail Elderly.(Brief Article)
2001 APR 4 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Frail elderly people may produce higher antibodies against flu if they get a double dose or booster dose of vaccine, but that response does not necessarily translate to improved protection.
"Responses to influenza vaccination are poor in frail elderly subjects who suffer the greatest morbidity and mortality due to infection," noted D.G. Roos-Van Eijndhoven and colleagues.
They conducted a randomized clinical trial to determine the effect of a double dose and booster influenza vaccination on antibody responses. The researchers randomized 815 nursing home patients with a median age of 83 years who were compromised by disease and disability to receive one of four vaccine strategies:
* a vaccine dose of 15 (micro)g followed by a booster dose of 15 (micro)g at 84 days
* a vaccine dose of 15 (micro)g followed by a placebo
* a vaccine dose of 30 (micro)g followed by a booster dose of 15 (micro)g
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