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Local Transmission Rates Determine If Vaccination Risks Outweigh Benefits.(Brief Article)
2001 APR 4 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Public health policy will have to take into account HIV transmission rates when addressing whether vaccination with live attenuated HIV is worth the risk.
In areas of high HIV transmission, the lives saved will outweigh possible transmission from the vaccine itself, but the opposite is true in areas of low transmission.
"Live attenuated HIV vaccines (LAHVs) could be extremely effective in protecting against infection with wild-type strains, but may not be completely safe as the attenuated strain could cause AIDS in some vaccinated individuals," noted S.M. Blower and colleagues at the University of California
Blower and team used data from Zimbabwe and Thailand to develop a mathematical model to predict the threshold past which LAVH risk outweighs its benefits.
They evaluated the potential impact of vaccination with 1,000 different LAHVs and predicted that in Zimbabwe, a high-transmission area, the benefit would outweigh the risks, but in Thailand, a low-transmission area, the LAHVs would have an overall detrimental effect on AIDS transmission ("Live attenuated HIV vaccines: Predicting the tradeoff between efficacy and safety," Proc ...
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Source: HighBeam Research, Local Transmission Rates Determine If Vaccination Risks Outweigh...