AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Cytokine-Secreting Vaccine Stops Metastatic Brain Tumors In Mice.(Brief Article)
2001 MAR 28 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Mice vaccinated with allogeneic fibroblasts that secrete interleukin 2 are less likely to develop metastatic brain tumors arising from breast cancer.
Because brain tumors develop in 15%-30% of patients with breast cancer, and are associated with high mortality despite the surgery-radiation-chemo armamentarium, P. Deshmukh and colleagues sought to develop a vaccine intervention.
"This study was designed to determine if an intracerebrally metastasizing breast tumor could be treated successfully with a cellular vaccine consisting of allogeneic fibroblasts (H-2(K)) modified to secrete interleukin (IL)-2," reported Deshmukh et al.
The authors measured lethal potential of spontaneously arising EO771 breast cancer cells injected into the frontal lobes of mice. Animals receiving 10(4) cells all died within 41 days. The researchers then administered a dose of 5x10(4) EO771 breast cancer cells into mice that had been vaccinated with 10(6) allogeneic fibroblasts genetically engineered to secrete IL-2.
Testing by enzyme-linked immunosorbent assay (ELISA) showed that the fibroblasts produced large quantities of IL-2, reported Deshmukh et al. ("Immunogene therapy with interleukin-2-secreting fibroblasts for intracerebrally metastasizing breast cancer in mice," Journal of Neurosurgery, 2001;94(2):287-292).
IL-2-vaccinated mice showed prolonged survival compared to controls that ...
- French abortion pill may help breast cancer, brain tumors, scientists say....
- Newspaper article from: Knight Ridder/Tribune News Service Vrazo, Fawn September 8, 1993 700+ words
...diseases ranging from breast cancer to benign brain tumors, a U.S. scientific...potential for treating breast cancer, since this type...life-threatening brain tumors that occur in both...California. In breast cancer and other areas...
- NeoPharm NDA for Broxuridine Breast Cancer Prognostic Indication Accepted for...
- Press release article from: PR Newswire March 3, 1997 700+ words
...prognostic indicator in breast cancer. After preliminary...malignant gliomas (brain tumors), is not sufficiently...000 new cases of breast cancer and 15,000 new cases...acceptance of the breast cancer NDA for review represents...
- U. California-Los Angeles: Medical student enlists aid of undergrads to...
- News wire article from: The America's Intelligence Wire June 1, 2004 700+ words
...After noticing that brain tumors in children tend to...suggesting pediatric brain tumors are the result of mutated...of cancer, notably breast cancer and leukemia, but the causes of pediatric brain tumors have been unclear...
- Proxima Therapeutics Announces FDA Approval of GliaSite(R) Radiation Therapy...
- Press release article from: PR Newswire May 8, 2001 700+ words
...treating malignant brain tumors." GliaSite...treatment for breast cancer that is currently...for breast and brain tumors also may have...for breast and brain tumors. Products include...early-stage breast cancer. Additional...
- CuraGen Announces Initiation of Phase II Trial of CR011-vcMMAE in Patients with...
- Press release article from: PR Newswire June 25, 2008 700+ words
...newly initiated study in breast cancer during the first half of...variety of cancers including breast cancer, melanoma, and brain tumors. CR011-vcMMAE is an antibody...invasion and metastasis of breast cancer cells. Furthermore, conjugating...
- Journal of Neurosurgery Study Finds GliaSite RTS Is a Safe and Effective...
- Press release article from: Business Wire August 5, 2003 700+ words
...therapy systems for brain and breast cancer, today announced publication...with recurrent malignant brain tumors, following surgical removal...treatment systems for breast and brain tumors. Products include GliaSite...cancer and MammoSite RTS for breast cancer. ...
- Former Globecomm Systems exec. develops breast cancer detection technology.
- Magazine article from: Long Island Business News August 8, 2003 700+ words
...with mammography to detect breast cancer and for follow-ups to gauge...infrared technology to treat breast cancer, a promising but still not...using its device to treat brain tumors as well as breast cancer.<P>The FDA...
- GlaxoSmithKline Announces Data on TYKERB(R) (Lapatinib) Plus Capecitabine for...
- Press release article from: PR Newswire December 17, 2007 700+ words
...Combination Reduced the Size of Brain Tumors Associated with HER2-Positive Breast Cancer SAN ANTONIO, Texas...reduction in HER2-positive breast cancer that had spread to the...positive metastatic breast cancer may develop brain metastases...
- Proxima Therapeutics Files for 510(k) Clearance for GliaSite(R) Radiation...
- Press release article from: PR Newswire October 23, 2000 700+ words
...treatment for malignant brain tumors," said Steve Tatter...radiation treatment for breast cancer that is currently in...systems for breast and brain tumors. Products include...RTS for early-stage breast cancer, which recently began...
- Certain brain tumors are clustered with other neoplasms in families.
- Newspaper article from: Cancer Gene Therapy Week March 22, 2004 700+ words
...histology-specific brain tumors with other cancers...9414 patients with brain tumors were identified from...SIRs) were found for brain tumors in association with...was associated with breast cancer," the researchers...
Source: HighBeam Research, Cytokine-Secreting Vaccine Stops Metastatic Brain Tumors In...