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Cytotoxic T Lymphocyte-Based Vaccine Prevents Infection In Mice.(Brief Article)
2001 MAR 28 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Researchers have demonstrated that mice vaccinated with Ebola virus nucleoprotein are completely protected from a lethal challenge of the viral hemorrhagic fever.
"Cytotoxic T lymphocytes (CTLs) are proposed to be critical for protection from intracellular pathogens such as Ebola virus. However, there have been no demonstrations that protection against Ebola virus is mediated by Ebola-virus-specific CTLs," noted Julie A. Wilson and colleagues at the U.S. Army Medical Research Institute of Infectious Diseases
Wilson et al. vaccinated mice with Venezuelan equine encephalitis virus replicons encoding the Ebola virus nucleoprotein (NP) and then challenged them with a lethal dose of Ebola virus.
Vaccinated mice exhibited antibodies to the NP and a major histocompatibility response, while unvaccinated mice were protected by adoptive transfer of CTLs specific for the Ebola virus NP ("Protection from Ebola virus mediated by cytotoxic T lymphocytes specific for the viral nucleoprotein," Journal of Virology, March 2001;75(6):2660-2664).
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Source: HighBeam Research, Cytotoxic T Lymphocyte-Based Vaccine Prevents Infection In...