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Yeast-Expressed Proteins Are Likely Vaccine Candidates.(Brief Article)
2001 MAR 28 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Antigens produced using a Saccharomyces cerevisiae protein expression system are considered good candidates for a malaria vaccine, say researchers at the U.S. National Institutes of Health.
A.W. Stowers and colleagues developed a recombinant protein expression system based on S. cerevisiae to produce antigens that show promise against malaria.
"They are all surface-exposed at some stage in the parasite's life cycle [and] they all share an unusual structural feature: epidermal growth factor (EGF)-like motifs," explained Stowers et al.
The researchers found that the proteins were stable structural conformers with biochemical and antigenic differences, such as the presence or absence of an antibody B-cell epitope ("Structural conformers produced during malaria vaccine production in yeast," Yeast, 2001;18(2):137-150).
"These findings have important ramifications for other EGF-domain-containing proteins expressed in S. cerevisiae, or for proteins which contain ...
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