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Worldwide Vaccine Program Could Eliminate CMV.(Brief Article)
2001 MAR 28 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Cytomegalovirus (CMV) is an ideal candidate for worldwide eradication through immunization, say researchers working in England.
"Using seroprevalence data from two large antenatal populations (in excess of 14,000 women) coupled with a mathematical modeling approach, we have shown that CMV has a low force of infection (ca. 0.03 per seronegative per annum) and its basic reproductive number R-0 is relatively modest at 2.4," reported P.D. Griffiths and colleagues.
Nevertheless, CMV is the leading cause of mental retardation in children, they noted.
The researchers calculated that the critical vaccination proportion needed for eradication would be 59%-62%. Furthermore, the rate of congenital infection would not increase following instigation of such a program, as was seen with the rubella vaccination program ("Encouraging prospects for immunization against primary cytomegalovirus infection," Vaccine, 2001;19(11-12):1356-1362).
"CMV is a prime ...
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