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DTaP Booster More Likely To Cause Local Reaction.(Brief Article)
2001 MAR 28 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Children receiving a fourth booster of diphtheria-tetanus-acellular pertussis vaccine are significantly more likely than those receiving a diphtheria-tetanus booster alone to have a localized reaction at the injection site.
Other side effects, such as fever and irritability, are similar in both groups, and immunogenicity of the fourth DTaP booster is high, researchers confirm.
A.E. Tozzi and colleagues conducted a study "to determine the reactogenicity and immunogenicity of a fourth dose of two three-component acellular pertussis vaccines combined with diphtheria-tetanus-acellular pertussis (DTaP) when administered at preschool age to children primed in infancy with three doses of the same DTaP and who had received a diphtheria-tetanus (DT) dose at the age of 12 months."
A group of 3,522 children in Italy was administered the DTaP vaccine in the first year of life, then offered it again at the age of five to six years. If the DTaP booster was refused, the children could be immunized with DT alone.
Though fever and irritability were somewhat uncommon side effects in both DTaP and DT groups (2.5%-4.8% and 10.1%-12.6%, respectively), local reactions occurred at a significantly higher rate in the DTaP group (44%-52.8%) than the DT group (29.5%-44.4%) ("Reactogenicity and immunogenicity at preschool age of a booster dose of two three-component diphtheria-tetanus-acellular pertussis vaccines in ...
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Source: HighBeam Research, DTaP Booster More Likely To Cause Local Reaction.(Brief Article)