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DNA Antigen May Lead To Development Of More Effective Vaccine.(Brief Article)
2001 MAR 28 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Immunization of mice with a DNA protein protects against leprosy infection at least as well as the Mycobacterium bovis bacille Calmette-Guerin (BCG) vaccine currently in use.
Leprosy remains a worldwide problem despite vaccination with BCG, and development of new vaccines is imperative, said E. Martin and colleagues at the Centenary Institute for Cancer Medicine and Cell Biology in Washington, DC.
"The immune dominant 35 kDa protein, shared [by] Mycobacterium leprae and M. avium, but not M. tuberculosis or BCG, is recognized by >90% of leprosy patients, making it an ideal candidate antigen for a subunit vaccine," proposed Martin et al.
The researchers found that mice immunized with a DNA-35 vaccine produced T cells and IFN-gamma and were protected against M. leprae footpad infection. The DNA-35 was at least as efficacious as the BCG vaccine ("DNA encoding a single mycobacterial antigen ...
- Manipulating dendritic cell biology provides active immunotherapy of cancer.
- Newspaper article from: Vaccine Weekly December 15, 2004 700+ words
...Manipulating dendritic cell biology provides active immunotherapy...Manipulating dendritic cell biology for the active immunotherapy...article was prepared by Vaccine Weekly editors from staff...Copyright 2004, Vaccine Weekly via NewsRx.com...
- Vaccine targets identified in intestinal M-cell biology.
- Newspaper article from: Vaccine Weekly July 16, 2003 700+ words
...joint research in intestinal M-cell biology, and announced Elan's further...existence of genes unique to M-cell biology and DGT and Elan's joint project...This article was prepared by Vaccine Weekly editors from staff and other...
- Leading Scientist Named New Chair of Cell Biology at Yale.
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- Researchers at Justus-Liebig University, Institute for Anatomy release new data...
- Newspaper article from: Biotech Week April 29, 2009 700+ words
...prospects of these organelles for pulmonary cell biology' new findings in cell biology. "Peroxisomes are intimately involved in...investigators in Giessen, Germany report (see also Cell Biology). "In this article, original results on...
- New cell biology research reported from Swinburne University of Technology.
- Newspaper article from: Biotech Week April 1, 2009 700+ words
Fresh data on cell biology are presented in the report 'A method...published in the journal Immunology and Cell Biology, "With new imaging technologies...has revolutionized many aspects of cell biology. A key goal now is to develop systems...
- Researchers from University of Lubeck, Center for Structural and Cell Biology...
- Newspaper article from: Life Science Weekly September 1, 2009 700+ words
...writing in the journal Histochemistry and Cell Biology report (see also Cell Biology). "We show that both GTP-and GDP-restricted...University of Lubeck, Center for Structural and Cell Biology in Medicine. The researchers concluded...
- Beta Cell Biology Consortium.
- Magazine article from: Environmental Health Perspectives December 1, 2000 700+ words
...seeking applications to establish a Beta Cell Biology Consortium for the purpose of intensifying...Through the consortium, individual Beta Cell Biology Programs will have access to information...such as developmental biology, stem cell biology, mouse genetics, imaging, ...
- New cell biology research from Northwestern University outlined.(Report)
- Newspaper article from: Science Letter November 18, 2008 700+ words
...research published in the Journal of Cell Biology, "To maintain polarity, epithelial...Northwestern University (see also Cell Biology). The researchers concluded: "Thus...published their study in the Journal of Cell Biology (Rab13 regulates membrane trafficking...
