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Outer Membrane Vesicles Cause Inflammatory Reaction To Meningococcal Vaccine.(Brief Article)
2001 MAR 28 - (NewsRx.com & NewsRx.net) --
by N.R. Saltmarsh, staff medical writer - Outer membrane vesicles of Neisseria meningitidis are responsible for the significant inflammatory local and systemic reactions to the Norwegian group B meningococcal outer membrane vesicle (OMV) vaccine.
The OMV vaccine consists of outer membrane proteins of N. meningitidis with large amounts of lipopolysaccharide, which researchers tested on human whole blood samples to study inflammatory effects.
"We have studied the ability of this OMV vaccine preparation to induce secretion of pro-inflammatory cytokines; tumor necrosis factor alpha (TNF-alpha); interleukin 1 beta (IL-1 beta), IL-6, IL-8; and anti-inflammatory cytokines, IL-4, IL-10 and IL-13, in a human whole blood model," said M.R. Mirlashari and colleagues working in Norway.
They observed a massive increase in plasma levels of TNF-alpha, IL-1 beta, IL-6, and IL-8 compared to control plasma samples ("Outer membrane vesicles from Neisseria meningitidis: Effects on cytokine production in human whole blood," Cytokine, 2001;13(2):91-97).
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