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Rats' Ovarian Function Loss Is Unrelated to Leptin Sensitivity Change.
2001 MAR 15 - (NewsRx.com & NewsRx.net) -- by Julie Crawshaw, staff medical writer -- Loss of ovarian function in rats is not related to a change in their sensitivity to leptin, researchers in the United States say.
Leptin levels are closely tied to fat levels, while menopause is associated with weight gain. Researchers investigated whether surgically-induced menopause in rats would affect sensitivity to leptin and found that it did not.
Yanyun Chen and colleagues at Lilly Research Labs studied leptin effects in Sprague-Dawley rats that received ovariectomies (OVX) or were sham-operated and given leptin injections for 35 days.
The Chen team found that injecting leptin into the OVX rats triggered hyperphagia and caused the rats to gain both more lean and fat mass. Injecting sham-operated rats with the same amount of leptin produced qualitatively similar data.
When Chen et al. assessed indirect calorimetry, they found that that OVX did not change the amount of energy the rats expended or their total level of fuel use ("Increased ...
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Source: HighBeam Research, Rats' Ovarian Function Loss Is Unrelated to Leptin Sensitivity Change.